There is no sin which does more deface God's image than drunkenness; it disguises a person and does even unman him. Drunkenness makes him have the throat of a fish, the belly of a swine, and the head of an ass. Drunkenness is the shame of nature, the extinguisher of reason, the shipwreck of chastity, and the murder of conscience. Drunkenness is hurtful for the body; the cup kills more than the cannon.
Our aim should be God's glory, but many drink to this end: that they may the easier forget God, forget Him in His threats which stick in their souls after sermon; forget Him in His judgments, which have taken hold of some of their companions. They drink to the end they may drown conscience and put off all thoughts of death and judgment; to the end they may harten [i.e., encourage] and harden themselves against all the messages of God and make themselves both to know and move at God's own words, as in this prophesy we find afterward. How many a man's heart can tell him that this hath been one of his special errands to the cup?
Take heed and beware of the detestable sin of drunkenness, which is a beastly sin, a voluntary madness, a sin that unmans thee and makes thee like the beasts that perish; yea, sets thee below the brute beasts, which will not drink to excess.
A drunkard is the annoyance of modesty, the spoiler of civility, the destruction of reason, the brewer's agent, the alehouse benefactor, his wife's sorrow, his children's trouble, his own shame, his neighbors' scoff, a walking swill bowl, the picture of a beast, and a monster of a man.
While the wine is in thy hand, thou art a man; when it is in thy head, thou art become a beast. The drunkard cries to his fellow, "Do me reason," but the drink answers, "I will leave thee no reason; scarce so much as a beast, for they will drink no more than they need." Diogenes being urged to drink immoderately cast the drink on the ground. Being reproved for that loss, he answered, "If I had drunk it, I had lost both the drink and myself."
drunkenness is to be avoided since it impairs cognitive function. This is why it "leads to reckless living." When cognitive function is impaired, people are less likely to act with care and more prone to act recklessly. The command stands in contrast to the Roman penchant for banquets, which were often characterized by drunkenness and debauchery. Moreover, some Greco-Roman religions regarded drunkenness as the means of achieving union with a god. Indeed, the cult of Dionysus, which was well-known within Ephesus, embraced the vine as their cultic symbol.Pillar Commentary, Ephesians